General Tips

Here are some tips that can be used throughout the game.

Population Management

 * Keep Morale as high as possible.
 * Morale lower than 100% reduces the production of everything, while high Morale boosts them.
 * Before researching Techno Wizards, Entertainers are fairly weak. Therefore it is best to have Democracy for this phase.
 * After reaching Space, low Morale is not any problem at all, so try to increase max Morale.
 * Don't keep citizens unemployed.
 * They lower morale even worse than employed citizens.
 * They don't pay taxes.
 * Try not to waste workforce.
 * Unassign workers when the resource is capped.

Construction

 * When going for MAD, you don't need so many buildings.
 * For Knowledge, we recommend 20-30 Libraries, about 20 Wardenclyffes, 9 Biolabs, and whatever number of Universities that can make your Knowledge cap at 120k or higher.
 * When having 9 Biolabs, genome sequencing takes about 1 hour and 40 minutes. It is good to try if your playstyle is idle.
 * You don't need any Wharves or Fission Reactors.
 * Wharves are not that powerful, and it costs Oil that is required for MAD Technology.
 * Although Power output of Fission Reactors is attractive, you will still get enough Power from Coal Powerplants, because you are plentiful of Coal anyway.
 * Only build 1 Factory to reveal Alloy.
 * It is less time-consuming to buy Alloy from Trade Routes than producing it.
 * After researching all the required Technologies for MAD, build as many Housing and Barracks as possible and wait for citizens and soldiers to fill up, as they directly influence your Plasmid gains.
 * Casinos are not worth the cost in MAD and Bioseed runs.
 * They cost $350K, while producing only up to $20 per second. It means that you have to wait almost 5 hours to get the money back.
 * In Bioseed runs, only buy them if you are short on Morale and it takes less time to build than Amphitheatre.

Technologies

 * Technology costing less Knowledge is not always easier to research.
 * They often cost a considerable amount of raw Materials.

Trade

 * Don't buy basic resources.
 * They are usually not worth the Money.
 * You can still buy advanced resources like Steel and Titanium as needed.
 * Selling surplus resource via Trade Routes is good for your economy.
 * You will have a huge surplus of Food, Lumber, and Stone.